کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5726267 | 1609726 | 2017 | 5 صفحه PDF | دانلود رایگان |
PurposeTo evaluate whether white matter tracts within the Papez circuit are altered in patients with unilateral hippocampal sclerosis (HS).MethodsTwenty patients with histologically proven unilateral HS and 20 age-matched controls were studied with a 3Â T Epilepsy-dedicated MRI protocol including a MPRAGE sequence for hippocampus volumetry and a diffusion tensor imaging (DTI) sequence (61 diffusion-encoding directions, 2Â ÃÂ 2Â ÃÂ 2Â mm3 voxels) for diffusion tensor tractography (DTT). An energy-based global tracking algorithm was used to calculate streamline counts (SC) and fractional anisotropy (FA) of cingulate, fornix, and mammillo-thalamic tracts, respectively.ResultsSclerotic hippocampi were significantly smaller compared to the contralateral side and to age-matched controls. Cingulum SC but not FA were reduced on the hippocampal sclerosis (258Â +Â 81.0) and contralateral side (271Â +Â 85.6) compared to age-matched controls (447Â +Â 138).ConclusionFocusing on white matter tracts of the Papez circuit we showed that in patients with intractable temporal lobe epilepsy unilateral hippocampal sclerosis is associated with a bilateral reduction of cingulum association fibers projecting from the cingulate gyrus to the parahippocampal gyrus.
Journal: European Journal of Radiology - Volume 94, September 2017, Pages 53-57