کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737657 | 1614717 | 2017 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anxiogenic effects of a Lactobacillus, inulin and the synbiotic on healthy juvenile rats
ترجمه فارسی عنوان
اثرات ضد انعقادی یک لاکتوباسیلوس، آنزیم و سین بیوئیک در موش های صحرایی نوجوانان
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کلمات کلیدی
CA1ACTHcentral area5-HT1AGPCREPMSSCDSSG protein-coupled receptors - G گیرنده های پروتئینی همراهShort chain fatty acids - اسیدهای چرب پایه کوتاهinterleukin - اینترلوکینelevated plus maze - بالا به همراه پیچ و خمELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاCNS - دستگاه عصبی مرکزیdigoxigenin - دیگوکسین ژنSaline Sodium Citrate - سدیم سدیم سدیمdextran sodium sulfate - سولفات سدیم سدیمcentral nervous system - سیستم عصبی مرکزیSynbiotic - سین بیوتیکDIG - شماLactobacillus - لاکتوباسیلوسGut-brain axis - محور خوب مغزOpen field - میدان بازadrenocorticotropic hormone - هورمون adrenocorticotropicHippocampus - هیپوکامپ prebiotic - پروبیوتیکCORT - کورتCorticosterone - کورتیکوسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Gut microbiota interventions, including probiotic and prebiotic use can alter behavior in adult animals and healthy volunteers. However, little is known about their effects in younger individuals. To investigate this, male Sprague-Dawley rats (post-natal day 21, PND21) received Lactobacillus casei 54-2-33 (104Â cfu/ml), inulin as prebiotic (16Â mg/ml), or both together (synbiotic) via drinking water for 14Â days. Control rats received water alone. Open field (OF) and elevated plus maze (EPM) behaviors were evaluated at PND34 and 35, respectively. 30Â min after EPM, brains and trunk blood were collected to evaluate hippocampal 5-HT1A (mRNA and protein) and plasma corticosterone (CORT). Lactobacillus, inulin and synbiotic-treated rats had fewer entries to the OF's center and spent more time in its periphery than controls. Synbiotic-fed rats explored the EPM's open arms longer than probiotic and inulin-fed rats. Synbiotic, but not Lactobacillus nor inulin-fed rats had lower levels of EPM-evoked CORT than controls. Basal CORT levels, evaluated in a naïve cohort, were higher in Lactobacillus- and inulin-fed rats than controls. In naïve synbiotic-fed rats, 5-HT1A mRNA levels were higher in dentate gyrus and cornus ammonis 1 layer (CA1), than in all other naïve groups, while hippocampal 5-HT1A protein levels were lower in bacteria-fed rats than controls. 5-HT1A mRNA changes suggest complex effects of gut microbes on hippocampal gene expression machinery, probably involving endogenous/exogenous bacteria and prebiotics interactions. Importantly, age might also influence their behavioral outcomes. Together, these data suggest that interventions in young rat microbiota evoke early behavioral changes upon stress, apparently in a hypothalamus-pituitary-adrenal axis independent fashion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 359, 17 September 2017, Pages 18-29
Journal: Neuroscience - Volume 359, 17 September 2017, Pages 18-29
نویسندگان
Camila Barrera-Bugueño, Ornella Realini, Jorge Escobar-Luna, Ramón Sotomayor-Zárate, Martin Gotteland, Marcela Julio-Pieper, Javier A. Bravo,