کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737963 | 1614730 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex
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کلمات کلیدی
PNDnAChRChaperoneEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدSprague–Dawley - اسپراگ داولیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDevelopment - رشدpostnatal day - روز پس از زایمانfrontal cortex - قشر جلوییAllosteric modulator - مدولاتور آلوده کنندهHIP - مفصل ران یا مفصل هیپHippocampus - هیپوکامپ nicotinic acetylcholine receptor - گیرنده استیلکولین نیکوتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The nicotinic acetylcholine receptor (nAChR) regulator chaperone (NACHO) was recently identified as an important regulator of nAChR maturation and surface expression. Here we show that NACHO levels decrease during early postnatal development in rats. This decrease occurs earlier and to a greater degree in the frontal cortex (FC) compared with the hippocampus (HIP). We further show that rats exposed to nicotine during pre- and postnatal development exhibit significantly higher NACHO levels in the FC at postnatal day (PND) 21, but not at PND60. Repeated exposure to nicotine selectively during early (PND8-14) or late (PND54-60) postnatal stages did not affect NACHO protein levels in the FC or HIP, neither did exposure to high doses of the selective α7 nAChR agonists SSR180711, A-582941, or PNU-282987. However, we found significantly increased NACHO protein levels in the FC of PND36 rats after a single exposure to a combination of nicotine and the type II α7 nAChR positive allosteric modulator (PAM) PNU-120596, but not the type I PAM AVL-3288. These findings suggest that exposure to nAChR agonism affects NACHO protein levels, and that this effect is more pronounced during pre- or early postnatal development. The effect of PNU-120596 further suggests that the increase in NACHO expression is caused by activation rather than desensitization of nAChRs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 346, 27 March 2017, Pages 278-283
Journal: Neuroscience - Volume 346, 27 March 2017, Pages 278-283
نویسندگان
Franziska Wichern, Majbrit M. Jensen, Ditte Z. Christensen, Jens D. Mikkelsen, Marjorie C. Gondré-Lewis, Morten S. Thomsen,