کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738237 | 1615042 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of neonatal microglia can be influenced by other neural cells
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کلمات کلیدی
E. coliTLR-4Cd11b/cLPSIL-6IL-1βRplp1qPCRDPBSNeurodevelopmental disorders - اختلالات عصبی توسعهEscherichia coli - اشریشیا کُلیinterleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βSex differences - تفاوت های جنسیتیtumor necrosis factor-α - تومور نکروز عامل αpostnatal day - روز پس از زایمانTNF-α - فاکتور نکروز توموری آلفاDulbecco’s phosphate buffered saline - فسفات باسیل نمک Dulbeccolipopolysaccharide - لیپوپلی ساکاریدMicroglia - میکروگلیاهاquantitative real-time polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی زمان واقعی استCell culture - کشت سلولAndrogen Receptor - گیرنده آندروژنیEstrogen receptor α - گیرنده استروژن αEstrogen receptor β - گیرنده استروژن βToll-like receptor 4 - گیرنده تله مانند 4
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
During development, microglial progenitor cells migrate into the brain from the periphery, a process critical to the maturation of the developing brain. Although they perform functions similar to mature, adult microglia, immature microglia are distinct from mature microglia. Activation of immature microglia, via an early-life immune challenge, can lead to persistent changes in microglial function, resulting in long-term neuronal and cognitive dysfunction. Early-life immune activation is associated with multiple neurodevelopmental disorders, including autism, ADHD, schizophrenia, and cerebral palsy - disorders with known or suspected immune etiologies, and strong sex biases for males. Activation of immature microglia requires further examination to determine its potential role in these neurodevelopmental disorders. More work is also necessary to better understand the relationship between developing microglia and other developing neural cells during this critical period of development. Thus, we treated freshly isolated, sex-specific microglia from the rat hippocampus with lipopolysaccharide (LPS) on P4, in either the presence or absence of other neural cells. Mixed and microglial-specific cultures were analyzed for inflammatory gene expression to determine whether immature microglia exhibited a sex-specific response to immune activation, and if the presence of all other neural cells influenced that response. We found that the microglial response to an LPS-induced immune activation differed depending on the presence of other neural cells in the culture. We found very few sex differences in the cytokine response, except that the microglial expression of IL-6 following immune activation was more robust in male microglia that were in the presence of other neural cells than female microglia in the same condition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 657, 14 September 2017, Pages 32-37
Journal: Neuroscience Letters - Volume 657, 14 September 2017, Pages 32-37
نویسندگان
Alexandra Turano, Jennifer H. Lawrence, Jaclyn M. Schwarz,