کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5739177 | 1615362 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The nature of early astroglial protection-Fast activation and signaling
ترجمه فارسی عنوان
طبیعت حفاظت از زود هنگام آسترگلایس - فعال سازی سریع و سیگنالینگ
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کلمات کلیدی
GDHGAT3AxDActivinAATAQP4AMPAEGFCX40Estradiol - استرادیولbeta-catenin - بتا کاتینینBED - بسترALS - بیماری اسکلروز جانبی آمیوتروفیکCNS - دستگاه عصبی مرکزیBBB - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیepidermal growth factor - عامل رشد اپیدرمیBlood-brain barrier - مانع خون مغزیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیGABA - گاباGABAAR - گابارGABABR - گابربEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Our present review is focusing on the uniqueness of balanced astroglial signaling. The balance of excitatory and inhibitory signaling within the CNS is mainly determined by sharp synaptic transients of excitatory glutamate (Glu) and inhibitory γ-aminobutyrate (GABA) acting on the sub-second timescale. Astroglia is involved in excitatory chemical transmission by taking up i) Glu through neurotransmitter-sodium transporters, ii) K+ released due to presynaptic action potential generation, and iii) water keeping osmotic pressure. Glu uptake-coupled Na+ influx may either ignite long-range astroglial Ca2+ transients or locally counteract over-excitation via astroglial GABA release and increased tonic inhibition. Imbalance of excitatory and inhibitory drives is associated with a number of disease conditions, including prevalent traumatic and ischaemic injuries or the emergence of epilepsy. Therefore, when addressing the potential of early therapeutic intervention, astroglial signaling functions combating progress of Glu excitotoxicity is of critical importance. We suggest, that excitotoxicity is linked primarily to over-excitation induced by the impairment of astroglial Glu uptake and/or GABA release. Within this framework, we discuss the acute alterations of Glu-cycling and metabolism and conjecture the therapeutic promise of regulation. We also confer the role played by key carrier proteins and enzymes as well as their interplay at the molecular, cellular, and organ levels. Moreover, based on our former studies, we offer potential prospect on the emerging theme of astroglial succinate sensing in course of Glu excitotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 153, June 2017, Pages 86-99
Journal: Progress in Neurobiology - Volume 153, June 2017, Pages 86-99
نویسندگان
Julianna Kardos, László Héja, Katalin Jemnitz, Richárd Kovács, Miklós Palkovits,