کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
575528 | 1453055 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanistic model for interpreting the toxic effects of sulfonamides on nitrification
ترجمه فارسی عنوان
مدل مکانیکی برای تفسیر اثرات سمی سولفونامید ها بر روی نیتریفیکاسیون
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کلمات کلیدی
PLSSASNORdhps - DPSAmmonia monooxygenase - آمونیاک مونوکسینژازQSAR - بزرگسال dihydropteroate synthetase - دی هیدروپرتات سینتاتازQuantitative Structure Activity Relationship - رابطه فعالیت ساختاری کمیPartial least squares regression - رگرسیون حداقل مربعات جزئیSulfonamides - سولفونامیدAMO - عشقQSAR model - مدل QSARToxicity mechanism - مکانیسم سمیتNitrite oxidoreductase - نیتریت اکسیدوردوکتازNitrification - نیتریفیکاسیونWastewater treatment plants - گیاهان تصفیه پساب
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
چکیده انگلیسی
Antibiotics are categorized as pseudopersistent compounds because of their widespread use and continuous emission into the environment. Biological systems such as active sludge and biofilms are still the principal tools used to remove antibiotics in wastewater treatment plants (WWTPs). Consequently, it is important to determine the relationship between toxic effects in biological WWTPs and the structural characteristics of antibiotics. In the present study, toxic effects of 10 sulfonamides (SAs) on nitrification in an active sludge system were studied. The toxicity results (half-effective concentrations, EC50) indicated that the toxicity of sulfadimethoxine (SDM) is approximately 4 times as large as that of sulfadiazine (SD). Based on the toxicity mechanism and the partial least squares regression (PLS) method, an optimum quantitative structure-activity relationship (QSAR) model was developed for the test system. The mechanistic model showed that the pKa, the binding energies between SAs with dihydropteroate synthetase (EbindingSAâDHPS) and the binding energies between SAs with ammonia monooxygenase (EbindingSAâAMO) are the key factors affecting the toxic effects of SAs on nitration process in active sludge system, following an order of importance of EbindingSAâDHPSÂ >Â EbindingSAâAMOÂ >Â pKa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 305, 15 March 2016, Pages 123-129
Journal: Journal of Hazardous Materials - Volume 305, 15 March 2016, Pages 123-129
نویسندگان
Xiangfeng Huang, Yi Feng, Cui Hu, Xiaoyu Xiao, Daliang Yu, Xiaoming Zou,