کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
575815 | 1453059 | 2016 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elucidation of biotransformation of diclofenac and 4â²hydroxydiclofenac during biological wastewater treatment
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کلمات کلیدی
LC-TOF-MSHRMSLOECDADNSAIDsRTSPEAGCHRTcpsLSCMBRWWTPSolid phase extraction - استخراج فاز جامدMembrane bioreactor - بیوراکتور غشاییdiode array detection - تشخیص آرایه دیودWastewater treatment plant - تصفیه خانه فاضلاب Wastewater treatment - تصفیه فاضلابNon-steroidal anti-inflammatory drugs - داروهای ضد التهابی غیر استروئیدیDiclofenac - دیکلوفناکSolids retention time - زمان نگهداری جامداتhydraulic retention time - زمان هیدرولیکیBiotransformation - زیستدگرگونیcounts per second - شمارش در هر ثانیهHigh resolution mass spectrometry - طیف سنجی جرمی با وضوح بالاTransformation products - محصولات ترانسفورماتورArbitrary Unit - واحد خودآموزlowest observed effect concentration - کمترین اثر غلظت مشاهده شدهautomatic gain control - کنترل اتوماتیک
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Elucidation of biotransformation of diclofenac and 4â²hydroxydiclofenac during biological wastewater treatment Elucidation of biotransformation of diclofenac and 4â²hydroxydiclofenac during biological wastewater treatment](/preview/png/575815.png)
چکیده انگلیسی
This study aimed at gaining knowledge on the degradation pathway during biological treatment of wastewater of diclofenac and 4â²-hydroxydiclofenac, its main human metabolite. For that purpose, an aerobic MBR was acclimatised to diclofenac, and the MBR biomass subsequently incubated with 14C-diclofenac or 14C-4â²hydroxydiclofenac over 25 days. It was demonstrated that diclofenac degradation was much slower and limited than that of 4â²-hydroxydiclofenac. Indeed, after 18 days of batch incubation, diclofenac was removed up to 40%, this rate remained stable till the end of the experiment, while 4â²-hydroxydiclofenac was completely degraded within nine days. The analyses of supernatant samples have shown that diclofenac degradation led to four transformation products, more polar than the parent compound, one of them being 4â²-hydroxydiclofenac. The degradation of 4â²-hydroxydiclofenac led to the formation of the same metabolites than those detected during diclofenac degradation. With these results, the hydroxylation of diclofenac to 4â²-hydroxydiclofenac was identified as one major bottleneck in diclofenac degradation during biological treatment of wastewater.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 301, 15 January 2016, Pages 443-452
Journal: Journal of Hazardous Materials - Volume 301, 15 January 2016, Pages 443-452
نویسندگان
Helene Bouju, Peter Nastold, Birgit Beck, Juliane Hollender, Philippe F.-X. Corvini, Thomas Wintgens,