کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
576249 | 1453077 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Troxerutin protects against 2,2â²,4,4â²-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion
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کلمات کلیدی
ALTinterleukin-lβPARP1NAMPTPBDEsBDE-47MCP-1Sirt1CyP4-hydroxynonenal4-HNEIL-6NF-κB2,2′,4,4′-Tetrabromodiphenyl ether - 2،2 '، 4،4'-تتررومودیفنیل اترF4/80 - F4 / 80NAD+ - NAD +ROS - ROSAlanine aminotransferase - آلانین آمینوترانسفرازinflammation - التهاب( توروم) interleukin-6 - اینترلوکین ۶Troxerutin - تروکسروتینOxidative stress - تنش اکسیداتیوtumor necrosis factor-α - تومور نکروز عامل αPolybrominated diphenyl ethers - دیفنیل اتر پلی بوروندیCytochrome P450 - سیتوکروم پی۴۵۰TNF-α - فاکتور نکروز توموری آلفاnuclear factor-κB - فاکتور هسته ای κBnicotinamide phosphoribosyltransferase - نیکوتین آمید فسفریبوسیل ترانسفرازNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1poly (ADP-ribose) polymerase-1 - پلی (ADP-ribose) پلیمراز-1Reactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Emerging evidence indicates that 2,2â²,4,4â²-tetrabromodiphenyl ether (BDE-47) induces liver injury through enhanced ROS production and lymphocytic infiltration, which may promote a liver inflammatory response. Antioxidants have been reported to attenuate the cellular toxicity associated with polybrominated diphenyl ethers (PBDEs). In this study, we investigated the effect of troxerutin, a trihydroxyethylated derivative of the natural bioflavonoid rutin, on BDE-47-induced liver inflammation and explored the potential mechanisms underlying this effect. Our results showed that NAD+-depletion was involved in the oxidative stress-mediated liver injury in a BDE-47 treated mouse model, which was confirmed by Vitamin E treatment. Furthermore, our data revealed that troxerutin effectively alleviated liver inflammation by mitigating oxidative stress-mediated NAD+-depletion in BDE-47 treated mice. Consequently, troxerutin remarkably restored SirT1 protein expression and activity in the livers of BDE-47-treated mice. Mechanistically, troxerutin dramatically repressed the nuclear translocation of NF-κB p65 and the acetylation of NF-κB p65 (Lys 310) and Histone H3 (Lys9) to abate the transcription of inflammatory genes in BDE-47-treated mouse livers. These inhibitory effects of troxerutin were markedly blunted by EX527 (SirT1 inhibitor) treatment. This study provides novel mechanistic insights into the toxicity of BDE-47 and indicates that troxerutin might be used in the prevention and therapy of BDE-47-induced hepatotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 283, 11 February 2015, Pages 98-109
Journal: Journal of Hazardous Materials - Volume 283, 11 February 2015, Pages 98-109
نویسندگان
Zi-Feng Zhang, Yan-qiu Zhang, Shao-Hua Fan, Juan Zhuang, Yuan-Lin Zheng, Jun Lu, Dong-Mei Wu, Qun Shan, Bin Hu,