You are never alone: crosstalk among epigenetic players

Different cell types in a certain organism contain the same genome while running diverse transcription programs. This is controlled by epigenetic information, including DNA modifications, histone modifications, histone variants, non-coding RNAs, and chromatin architectures. Interestingly, recent progresses revealed extensive crosstalks among these epigenetic players. We discuss here how epigenetic players coordinate with each other to maintain epigenetic identities in mammal cells. More exciting researches are expected to expand our understanding regarding the epigenetic regulatory network.