کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
579851 | 1453143 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance
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کلمات کلیدی
FSIGTTCDDHOMA-IRPCBsPCP2,3,7,8-Tetrachlorodibenzo-p-dioxin - 2،3،7،8-تترا کلریدیبنزوپتوفان دیوکسینPolychlorinated dibenzo-p-dioxins and dibenzofurans - dibenzo-p-dioxins و dibenzofurans پلی کربناتPCDD/Fs - PCDD / FsPOPs - آلایندههای آلی دیرپاPersistent organic pollutants - آلایندههای آلی دیرپا(پایدار)Polychlorinated biphenyls - بیفنیل پلیکلر Triglycerides - تریگلیسریدMercury - جیوهType 2 diabetes - دیابت نوع 2Dioxins - دیوکسین هاMetabolic syndrome - سندرم متابولیکMETS - متسInsulin resistance - مقاومت به انسولینPentachlorophenol - پنتا کلروفنل
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
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چکیده انگلیسی
Insulin resistance and the defective function of pancreatic β-cells can occur several years before the development of type 2 diabetes. It is necessary to investigate and clarify the integrated effects of moderate-to-high exposure to dioxins and mercury on the pancreatic endocrine function. This cross-sectional study investigated 1449 non-diabetic residents near a deserted pentachlorophenol and chloralkali factory. Metabolic syndrome related factors were measured to examine associations with serum dioxin and blood mercury. We also investigated associations between insulin resistance (HOMA-IR > 75th percentile), defective pancreatic β-cells function (HOMA β-cell > 75th percentile), serum dioxins and blood mercury. After adjusting for confounding factors, we found that insulin resistance increased with serum dioxins (b = 0.13, P < 0.001) and blood mercury (b = 0.01, P < 0.001). Moreover, participants with higher serum dioxins or blood mercury were at a significantly increasing risk for insulin resistance (Ptrend < 0.001). The joint highest tertile of serum dioxins and blood mercury was associated with elevated HOMA-IR at 11 times the odds of the joint lowest tertile (AOR 11.00, 95% CI: 4.87, 26.63). We hypothesize that simultaneous exposure to dioxins and mercury heightens the risk of insulin resistance more than does individual exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 185, Issues 2â3, 30 January 2011, Pages 749-755
Journal: Journal of Hazardous Materials - Volume 185, Issues 2â3, 30 January 2011, Pages 749-755
نویسندگان
Jung-Wei Chang, Hsiu-Ling Chen, Huey-Jen Su, Po-Chi Liao, How-Ran Guo, Ching-Chang Lee,