کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5799835 1555342 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emergence of a Pseudorabies virus variant with increased virulence to piglets
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Emergence of a Pseudorabies virus variant with increased virulence to piglets
چکیده انگلیسی


- PRV variant JS-2012 was more pathogenic to pigs as compared with classical SC strain.
- Bartha-K61 vaccination provided partial protection against challenge with PRV JS-2012
- Bartha-K61 vaccination provided complete protection against challenge with PRV SC.

Pseudorabies virus (PRV) causes Pseudorabies (PR), an economically important disease in domestic swine. PR outbreaks on pig farms caused by PRV variant strains in Bartha-K61-vaccinated pigs have resulted in considerable economic losses in China since 2011. In this study, the pathogenicity of the PRV variant JS-2012 strain to pigs was investigated by experimentally inoculating piglets of different ages in comparison with a classic virulent PRV SC strain. The JS-2012 strain caused an earlier onset of clinical signs and higher mortality in 15, 30, and 60-day-old pigs, as compared with a classic virulent PRV SC strain. The Bartha-K61 vaccination provided complete protection against challenge with classical virulent PRV, but only partial protection against challenge with the JS-2012 strain in piglets. In conclusion, the increased virulence of the PRV variant may have partly contributed to the PR outbreak in China.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 181, Issues 3–4, 31 December 2015, Pages 236-240
نویسندگان
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