کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5800069 1555354 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant
ترجمه فارسی عنوان
دوباره ظهور ویروس سندرم تنفسی و تولید مثل (خوک 3) و افزایش پاتوژنیک پس از نوترکیب ژنوم با نوع واکسن
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


- Three lineages (lineage 3, 5.1 and 8.7) of PRRV were circulating in South China.
- Inter-lineage genomic recombination was found between wild type and MLV.
- GM2 was the recombinant and the QYYZ was the wild type.

Porcine reproductive and respiratory syndrome virus (PRRSV) was first reported in China since late 1995 and several variants were further reported in subsequence years, causing huge economic losses to the Chinese swine industry. To date, three major lineages (lineage 3, 5.1 and 8.7) of Type 2 PRRSV were reported in China based on our global genotyping. The present study provides the epidemiology of the PRRSV in South China based on the isolates collected during 2009-2012, indicating three lineages (lineage 3, 5.1 and 8.7) of Type 2 PRRSV were still circulating in this area. Our phylogenetic reconstruction indicated that lineage 3 re-emerged in 2010 formed a huge cluster with closely related to the 2004 isolates from Hong Kong. Furthermore, the inter-lineage genomic recombination between MLV vaccine strain (lineage 5) and a recently re-emerged lineage 3 virus (QYYZ) has also been found in a farm practicing MLV vaccination. Our in vivo experiment comparing the pathogenicity and clinical presentations among currently isolated viruses indicated that pigs infected with recombinant lineage 3 virus (GM2) showed persistent higher fever compared to pigs infected by its wild counterpart (QYYZ). This study enhanced our understanding on potential importance of the recombination of PRRSV along with their evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 175, Issues 2–4, 25 February 2015, Pages 332-340
نویسندگان
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