Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats

► Aging increased BDNF immunocontent and caffeine counteracted to adult levels. ► Caffeine did not modify aged-related decrease in TrkB immunocontent. ► Caffeine increased proBDNF and CREB immunocontent. ► Caffeine counteracted age-associated memory impairment.