Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

► Selective 5-HT2CR activation potently decreases the reinforcing efficacy of cocaine and sucrose in freely-fed rats. ► The novel, selective 5-HT2CR agonist WAY 163909 differentially alters cue-evoked cocaine-, but not sucrose-reinstatement. ► WAY 163909 suppresses these behaviors at doses ∼5-12-fold lower than those predicted to suppress horizontal ambulation.