کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5817611 | 1557309 | 2016 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pharmaceutical NanotechnologyBioavailability of curcumin and curcumin glucuronide in the central nervous system of mice after oral delivery of nano-curcumin Pharmaceutical NanotechnologyBioavailability of curcumin and curcumin glucuronide in the central nervous system of mice after oral delivery of nano-curcumin](/preview/png/5817611.png)
Curcumin is a bioactive molecule extracted from Turmeric roots that has been recognized to possess a wide variety of important biological activities. Despite its great pharmacological activities, curcumin is highly hydrophobic, which results in poor bioavailability. We have formulated this hydrophobic compound into stable polymeric nanoparticles (nano-curcumin) to enhance its oral absorption. Pharmacokinetic analysis after oral delivery of nano-curcumin in mice demonstrated approximately 20-fold reduction in dose requirement when compared to unformulated curcumin to achieve comparable plasma and central nervous system (CNS) tissue concentrations. This investigation corroborated our previous study of curcumin functionality of attenuating opioid tolerance and dependence, which shows equivalent efficacy of low-dose (20Â mg/kg) nano-curcumin and high-dose (400Â mg/kg) pure curcumin in mice. Furthermore, the highly selective and validated liquid chromatographyâ¿¿mass spectrometry (LCâ¿¿MS) method was developed to quantify curcumin glucuronide, the major metabolite of curcumin. The results suggest that the presence of curcumin in the CNS is essential for prevention and reversal of opioid tolerance and dependence.
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Journal: International Journal of Pharmaceutics - Volume 511, Issue 1, 10 September 2016, Pages 415-423