کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5818894 1557338 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tuning dual-drug release from composite scaffolds for bone regeneration
ترجمه فارسی عنوان
تنظیم انتشار دو داروی داربست کامپوزیت برای بازسازی استخوان
کلمات کلیدی
سیستم تحویل دو دارو، داربست متخلخل طراحی شده، ایبوپروفن اسید زولدرونیک، انتشار همزمان مهندسی بافت،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

This work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (anti-inflammatory drug) were successfully incorporated in a controlled manner into three dimensional designed porous scaffolds of apatite/agarose composite. A high-performance liquid chromatography method was optimized to separate and simultaneously quantify the two drugs released from the dual-drug codelivery system. The multifunctional porous scaffolds fabricated show a very rapid delivery of anti-inflammatory (interesting to reduce inflammation after implantation), whereas the anti-osteoporotic drug showed sustained release behaviour (important to promote bone regeneration). Since ibuprofen release was faster than desired, this drug was encapsulated in chitosan spheres which were then incorporated into the scaffolds, obtaining a release profile suitable for clinical application. The results obtained open the possibility to simultaneously incorporate two or more drugs to an osseous implant in a controlled way improving it for bone healing application.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 486, Issues 1–2, 30 May 2015, Pages 30-37
نویسندگان
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