کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5819999 | 1557375 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ex vivo absorption of promestriene from oil-in-water emulsion into infant foreskin
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
Hypospadias is a birth defect in which the urinary tract opening is not at the tip of the penis. Hypospadias surgery is frequently complicated by healing deficiencies. Topical treatments with oestrogens were reported to improve healing. In the present study, ex vivo percutaneous absorption of promestriene, a synthetic oestrogen resulting of the double esterification of estradiol was conducted as a pre-requisite for further clinical trial in infants. Penetration of promestriene into infant foreskin treated with commercial oil in water emulsion (10 μg mgâ1) for 24 h was characterized showing controlled release properties enabling epidermal concentration more than six times higher than dermal concentration (4.13 ± 2.46 mg gâ1 versus 0.62 ± 0.84 mg gâ1, respectively). Furthermore, apparent promestriene fluxes into and through the skin (i.e., 1.5 μg cmâ2 hâ1 and < 0.89 μg cmâ2 hâ1, respectively) were calculated from (i) drug amount retained into epidermis and dermis, or (ii) the limit of detection into the receptor fluid. In conclusion, less than 2% of initial dose were absorbed within 24 h which compared well with others steroids applied topically in colloidal systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 456, Issue 1, 1 November 2013, Pages 121-124
Journal: International Journal of Pharmaceutics - Volume 456, Issue 1, 1 November 2013, Pages 121-124
نویسندگان
D. Salmon, B. Kassai, L. Roussel, P. Mouriquand, C. Gérard, D.B. Gorduza, C. Serre, F. Falson, C. Pivot, F. Pirot,