کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5820175 1557377 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide
چکیده انگلیسی
The miniCD4 M48U1 was formulated into thermosensitive and mucoadhesive pluronic® hydrogels as anti-HIV-1 microbicide. The release kinetics of M48U1 from F127/HPMC (20/1 wt%) and F127/F68/HPMC (22.5/2.5/1 wt%) studied during 24 h by using Franz diffusion cells showed that HEC hydrogel (1.5 wt%) used as control released 93% of the peptide, while about 25% of M48U1 remained in pluronic® hydrogels. The formulation of M48U1 in pluronic® hydrogels ensures a local delivery because no diffusion of the peptide was detected through vaginal Cynomolgus macaque mucosa using Ussing chamber. Finally, toxicological studies showed no significant difference in the HeLa cell viability of the pluronic® hydrogels in comparison with HEC and phosphate buffer saline.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 454, Issue 2, 1 October 2013, Pages 649-652
نویسندگان
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