کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5820222 1557387 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modeling solid-state transformations occurring in dissolution testing
ترجمه فارسی عنوان
مدل سازی حالت های حالت جامد در آزمایش انحلال
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Changes in the solid-state form can occur during dissolution testing of drugs. This can often complicate interpretation of results. Additionally, there can be several mechanisms through which such a change proceeds, e.g. solvent-mediated transformation or crystal growth within the drug material itself. Here, a mathematical model was constructed to study the dissolution testing of a material, which undergoes such changes. The model consisted of two processes: the recrystallization of the drug from a supersaturated liquid state caused by the dissolution of the more soluble solid form and the crystal growth of the stable solid form at the surface of the drug formulation. Comparison to experimental data on theophylline dissolution showed that the results obtained with the model matched real solid-state changes and that it was able to distinguish between cases where the transformation was controlled either by solvent-mediated crystallization or solid-state crystal growth

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 447, Issues 1–2, 15 April 2013, Pages 218-223
نویسندگان
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