کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5820314 1557393 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmaceutical NanotechnologyA prototype 'Infucon' device for continuous infusion of microbubbles in vivo
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Pharmaceutical NanotechnologyA prototype 'Infucon' device for continuous infusion of microbubbles in vivo
چکیده انگلیسی

A device for continuous infusion of microbubbles (MBs) 'Infucon' has been designed, constructed and tested on rabbits. The device prevents MBs from flotation and accumulation in the layer directly below the surface in the syringe injection during i.v. application. Homogenous i.v. application of MBs was tested on 16 male New Zealand White rabbits (average weight about 3.5 kg). Two sorts of MBs were used - a set of commercial SonoVue diagnostic microbubbles (Bracco) and pegylated DPPC microbubbles (PegMBs), which had been prepared in our laboratory. Sulphur hexafluoride was used as a filling gas. The application of MBs by continuous infusion via Infucon prolonged the ultrasound signal period in the heart of the rabbit to 12 min in comparison to about 1 min observed in bolus application. No adverse effects were observed on the tested rabbits after the MB application via Infucon. The principle employed in the prototype device Infucon could be used for development of the device intended for clinical applications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 441, Issues 1–2, 30 January 2013, Pages 92-98
نویسندگان
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