کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5820321 | 1557393 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs
ترجمه فارسی عنوان
پروتئین های غذایی به عنوان تثبیت کننده های جدید نانوسوزپنج برای داروهای محلول در آب بسیار کم است
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
نانوساختن، پروتئین های غذایی، داروهای محلول در آب بسیار ضعیف است تثبیت کننده ها،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
چکیده انگلیسی
Nanonization of the poorly water-soluble drugs is a promising strategy to improve dissolution and oral bioavailability. To stabilize the drug nanosuspensions, stabilizers are usually used; however, the use of common stabilizers is limited by weak stabilization effect and toxicological concerns for long-term treatment. The present work was to investigate the potential of food proteins as novel safe stabilizers for nanosuspensions using indomethacin as a model drug. The nanosuspensions stabilized by food proteins (soybean protein isolate, whey protein isolate and β-lactoglobulin) were prepared by the nanoprecipitation-ultrasonication method. The particle size could be easily reduced to 100-400 nm with bimodal particle-size distribution through monitoring the preparative variables. The exposure of buried hydrophobic moieties due to heat-denaturation and subsequent adsorption onto the surface of drug particles was assumed to contribute to their efficient stabilization effect. In comparison with conventional stabilizers, food proteins are superior in stabilization efficiency. The dissolution was enhanced significantly owing to particle size reduction. The protein-stabilized nanosuspensions could be easily freeze-fried and reconstituted into nanosuspensions, keeping the original mean particle size and particle-size distribution. It is concluded that the three denatured proteins perform as efficient stabilizers for indomethacin nanosuspensions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 441, Issues 1â2, 30 January 2013, Pages 269-278
Journal: International Journal of Pharmaceutics - Volume 441, Issues 1â2, 30 January 2013, Pages 269-278
نویسندگان
Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Fuqiang Hu, Wei Wu,