کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5820337 | 1557393 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dexamethasone eye drops containing γ-cyclodextrin-based nanogels
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sustained release aqueous eye drops of dexamethasone, based on cyclodextrin (CD) nanogels, were designed and tested in vivo. γCD units were cross-linked in the form of nanogels by means of an emulsification/solvent evaporation process. The composition of the nanogels was optimized with regard to drug loading and release rate. The eye drops consisted of an aqueous solution of dexamethasone in 2-hydroxypropyl-γ-cyclodextrin (HPγCD) medium containing γCD nanogels. The nanogel eye drops (containing 25 mg dexamethasone per ml) were tested in rabbits and compared to the commercially available product Maxidex® (suspension with 1 mg dexamethasone per ml). One drop administration of the nanogel eye drops resulted in nearly constant dexamethasone concentration for at least 6 h in the tear fluid (mean concentration ± SD = 295 ± 59 μg/ml) whereas the concentration after administration of Maxidex® fell rapidly from 9.72 ± 3.45 μg/ml 1 h after application to 3.76 ± 3.26 μg/ml 3 h after application. The maximum dexamethasone concentration in the aqueous humor (2 h after application) was 136 ± 24 mg/ml after application of the nanogel eye drops, and only 44.4 ± 7.8 μg/ml after application of Maxidex®. The dexamethasone nanogel eye drops were well tolerated with no macroscopic signs of irritation, redness or other toxic effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 441, Issues 1â2, 30 January 2013, Pages 507-515
Journal: International Journal of Pharmaceutics - Volume 441, Issues 1â2, 30 January 2013, Pages 507-515
نویسندگان
Maria D. Moya-Ortega, Tiago F.G. Alves, Carmen Alvarez-Lorenzo, Angel Concheiro, Einar Stefánsson, Margrét Thorsteinsdóttir, Thorsteinn Loftsson,