کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5820347 1557393 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release
چکیده انگلیسی

Lysozyme (Ly) and sodium carboxymethyl cellulose (CMC) were used to fabricate nanogels by a convenient method without using any chemical treatment except simple heating to achieve the denaturation temperature of Ly. The prepared nanogels were characterized by dynamic laser scattering (DLS), rheological analysis, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The nanogels are of spherical shape with average hydrodynamic diameter of 241 nm and the swelling ratio of nanogels is about 5. Then 5-fluorouracil was used as a model drug to investigate the entrapment efficiency and release ability in nanogels. It turned out to be that the release in simulated gastric fluid (SGF) was more slowly compared with that in simulated intestinal fluid (SIF), which could protect the 5-Fu in stomach and ensure it released in intestines.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 441, Issues 1–2, 30 January 2013, Pages 721-727
نویسندگان
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