کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5820535 | 1557402 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Polysorbate 80 coated poly (É-caprolactone)-poly (ethylene glycol)-poly (É-caprolactone) micelles for paclitaxel delivery Polysorbate 80 coated poly (É-caprolactone)-poly (ethylene glycol)-poly (É-caprolactone) micelles for paclitaxel delivery](/preview/png/5820535.png)
In this article, polysorbate 80 coated poly (É-caprolactone)-poly (ethylene glycol)-poly (É-caprolactone) (PCEC) micelles were successfully prepared for paclitaxel (PTX) delivery. The particle size distribution, morphology, drug loading, encapsulation efficiency and sustained release profile of the micelles were studied in detail. The safety of the micelle formulation was evaluated by MTT assay on HEK293 cells. And the encapsulated PTX in the micelles remained potent antitumor effect on C6 glioma cells. The pharmacokinetic study showed that the PCEC micelles coated with polysorbate 80 altered the biodistribution pattern and increased PTX concentration in the brain significantly compared to the uncoated micelles and the free drug after intravenous injection. The results indicated that polysorbate 80 coated PCEC micelles might be a candidate for PTX delivery for brain tumor chemotherapy.
PTX concentrations in different organs after intravenous injection of PTX formulations: (A) brain, (B) heart, (C) liver, (D) spleen, (E) lung, (F) kidney.96
Journal: International Journal of Pharmaceutics - Volume 434, Issues 1â2, 15 September 2012, Pages 1-8