کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5820792 | 1557399 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis
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کلمات کلیدی
CFURESAMBAmphotericin B - آمفوتریسین BEfficacy - اثرTID - زمانthree times a day - سه بار در روزReticuloendothelial system - سیستم رتیکولواندوتلیالLipid-based formulations - فرمول های مبتنی بر لیپیدRats - موش صحراییCandida albicans - کاندیدا آلبیکنسInvasive candidiasis - کاندیدیازیس تهاجمیhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراcolony forming unit - کلنی واحد تشکیل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
The objective of this work was to assess the antifungal activity of a tropically stable formulation of amphotericin B (AmB) (iCo-010) over short period of treatment in a rat model of invasive candidiasis. The rats were infected with Candida albicans (ATCC 18804); 48Â h later, the animals were assigned either to a control group, AmBisome® group (5Â mg/kg QD), or iCo-010 groups (0.5, 1, 2.5, 5 and 10Â mg/kg TID). The animals were treated for two days and then sacrificed 18Â h following the completion of the treatment. The blood, liver, lungs, kidneys and spleen were harvested to assess the colony forming units in the samples. There was no significant difference in the reduction of the fungal burden in the organs between the AmBisome® and iCo-010 groups except in the spleen and liver. There was a linear correlation between the antifungal activity in renal tissues and the administered doses of iCo-010. The plasma creatinine levels were not significantly different among the control and all the treatment groups. Oral iCo-010 has high efficacy against invasive candidiasis in renal and pulmonary tissues. Longer treatment period than the two-days regimen should be considered for higher therapeutic efficacy of iCo-010 in all the tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 436, Issues 1â2, 15 October 2012, Pages 318-323
Journal: International Journal of Pharmaceutics - Volume 436, Issues 1â2, 15 October 2012, Pages 318-323
نویسندگان
Fady Ibrahim, Pavel Gershkovich, Olena Sivak, Ellen K. Wasan, Karen Bartlett, Kishor M. Wasan,