Poly(amido)amine dendrimers generation 4.0 (PAMAM G4) reduce blood hyperglycaemia and restore impaired blood-brain barrier permeability in streptozotocin diabetes in rats

(A) Hyperglycaemia (glucose) disrupts blood-brain barrier (BBB) integrity leading to leakage of molecules (fluorescein) from blood into brain parenchyma. (B) Dendrimers (PAMAM) scavenge glucose excess and restore BBB integrity.