کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5821369 | 1557439 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and characterization of site specific target sensitive liposomes for the delivery of thrombolytic agents
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development and characterization of site specific target sensitive liposomes for the delivery of thrombolytic agents Development and characterization of site specific target sensitive liposomes for the delivery of thrombolytic agents](/preview/png/5821369.png)
چکیده انگلیسی
In recent times, search for potent and highly selective thrombolytic agents with minimal side effects has become a major area of research. The aim of the present study was to develop and characterize target sensitive (TS) liposomes encapsulating streptokinase, a thrombolytic agent. The developed TS liposomes were composed of dioleylphophatidyl ethanolamine (DOPE) and dipalmityl-c(RGDfK) (10:1Â mol/mol). Dipalmityl-c(RGDfK) was synthesized using typical carbodiimide chemistry using palmitic acid and c(RGDfK), while lysine was used as a spacer. Liposomes were of 100-120Â nm size. In vitro drug release study showed that nearly 40% drug of the entrapped drug was released in 12Â h in the PBS (pH 7.4), however on incubation with activated platelet about 90% of drug was released within 45Â min. The results suggested target sensitivity of the liposomes. Further, targeting potential was confirmed using fluorescent microscopy and flow cytometry. Clot lysis study revealed that TS liposomes could not only reduce the clot lysis time but also increase the extent of clot lysis as compared to non-liposomal streptokinase solution. In conclusion, the present liposomal formulation will target the thrombolytic agent to the activated platelets in the thrombus and hence will improve the therapeutic efficacy of the drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 403, Issues 1â2, 17 January 2011, Pages 254-261
Journal: International Journal of Pharmaceutics - Volume 403, Issues 1â2, 17 January 2011, Pages 254-261
نویسندگان
Bhuvaneshwar Vaidya, Manasa K. Nayak, Debabrata Dash, G.P. Agrawal, Suresh P. Vyas,