کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5821552 1557809 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Suramin treatment reduces chikungunya pathogenesis in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Suramin treatment reduces chikungunya pathogenesis in mice
چکیده انگلیسی


- Suramin treatment reduces viral burden in CHIKV-infected mice.
- Suramin treatment alleviates CHIKV-induced foot swelling in mice.
- Suramin treatment ameliorates musculoskeletal lesions in CHIKV-infected mice.

The chikungunya virus (CHIKV), an arthritogenic alphavirus, has caused explosive epidemics involving millions of cases. Globally expanding pandemics involving CHIKV and post-CHIKV rheumatic disorders are increasing public health concerns. However, no antiviral interventions or vaccines to control CHIKV infection have yet been approved. Although suramin has been possess anti-CHIKV activity in vitro, whether suramin has anti-CHIKV activity in vivo remains unknown. This study aimed to determine whether suramin treatment could ameliorate CHIKV-induced arthritis in a C57BL/6 mice model.C57BL/6 mice were infected with CHIKVs to evaluate anti-CHIKV activities of suramin in terms of histopathology, viral burden and disease score. Not only did suramin treatment substantially decrease viral loads, but it also significantly ameliorated acute foot lesions in mice. In addition, suramin treatment markedly restores cartilage integrity and reduces the number of IHC positive chondrocyte in mice infected with CHIKV strains 0810bTw and 0706aTw. This in vivo study highlights the potential ability of suramin to treat CHIKV infection in clinical settings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 134, October 2016, Pages 89-96
نویسندگان
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