کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5821604 1557811 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library
ترجمه فارسی عنوان
شناسایی مهارکننده های ورودی ویروسهای مبتلا به ویروس ابولا از کتابخانه ترکیبی مایکوباکتریال
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Myxobacteria produce secondary metabolites many of which were described to have various biological effects including anti-fungal, anti-bacterial and anti-viral activity. The majority of these metabolites are novel scaffolds with unique modes-of-action and hence might be potential leads for drug discovery. Here, we tested a myxobacterial natural product library for compounds with inhibitory activity against Ebola virus (EBOV). The assay was performed with a surrogate system using Ebola envelope glycoprotein (GP) pseudotyped lentiviral vectors. EBOV specificity was proven by counter-screening with vesicular stomatitis virus G protein pseudotyped vectors. Two compounds were identified that preferentially inhibited EBOV GP mediated cell entry: Chondramides that act on the actin skeleton but might be too toxic and noricumazole A, a potassium channel inhibitor, which might constitute a novel pathway to inhibit Ebola virus cell entry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 132, August 2016, Pages 85-91
نویسندگان
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