کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5821829 | 1557821 | 2015 | 9 صفحه PDF | دانلود رایگان |
- New steroidal pregnenolone derivatives substituted at C-16 were synthesized.
- Several derivatives showed an in vitro inhibitory effect on HSV-1.
- Inhibition of both wild type and ACV-resistant strains was observed.
- The compounds seem to interfere with the late steps of the viral cycle.
The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus, the development of new antiherpetic compounds remains as a central challenge. In this work we describe the synthesis and the in vitro antiherpetic activity of a new family of steroidal compounds derived from the endogenous hormone pregnenolone. Some of these derivatives showed a remarkable inhibitory effect on HSV-1 spread both on wild type and ACV-resistant strains. The results also show that these compounds seem to interfere with the late steps of the viral cycle.
Journal: Antiviral Research - Volume 122, October 2015, Pages 55-63