|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5821985||1557818||2016||5 صفحه PDF||سفارش دهید||دانلود رایگان|
- Combination treatment with GCV and tricin to HCMV replication was studied.
- We found strong synergistic effects on HCMV replication by GCV and tricin.
- Tricin is a novel compound for combination therapy with GCV against HCMV replication.
It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4â²,5,7-trihydroxy-3â²,5â² -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the anti-HCMV effects of GCV plus various concentrations of tricin, and tricin plus various concentrations of GCV in MRC-5 cells. We found that expression of the HCMV UL54 gene was significantly inhibited by combination of GCV with tricin when compared with GCV mono-treatment. These results suggest that tricin is a novel compound for combination therapy with GCV against HCMV replication. In addition, reduced-dose combination therapy may provide a direction for treatment in patients with HCMV infection while reducing drug toxicity.
Journal: Antiviral Research - Volume 125, January 2016, Pages 79-83