کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5821985 1557818 2016 5 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic effects by combination of ganciclovir and tricin on human cytomegalovirus replication in vitro
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موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Synergistic effects by combination of ganciclovir and tricin on human cytomegalovirus replication in vitro
چکیده انگلیسی


- Combination treatment with GCV and tricin to HCMV replication was studied.
- We found strong synergistic effects on HCMV replication by GCV and tricin.
- Tricin is a novel compound for combination therapy with GCV against HCMV replication.

It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4′,5,7-trihydroxy-3′,5′ -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the anti-HCMV effects of GCV plus various concentrations of tricin, and tricin plus various concentrations of GCV in MRC-5 cells. We found that expression of the HCMV UL54 gene was significantly inhibited by combination of GCV with tricin when compared with GCV mono-treatment. These results suggest that tricin is a novel compound for combination therapy with GCV against HCMV replication. In addition, reduced-dose combination therapy may provide a direction for treatment in patients with HCMV infection while reducing drug toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 125, January 2016, Pages 79-83
نویسندگان
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