کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5822000 | 1557824 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Common adverse events associated with ribavirin therapy for Severe Fever with Thrombocytopenia Syndrome
ترجمه فارسی عنوان
عوارض جانبی ناگهانی مرتبط با درمان ریباویرین برای تب شدید با سندرم ترومبوسیتوپنی
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کلمات کلیدی
تب شدید با سندرم ترومبوسیتوپنی، ریباویرین، رویداد جانبی، هیپرامیلوزمی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Severe Fever with Thrombocytopenia Syndrome (SFTS) is associated with high mortality rate, for which antiviral therapy with ribavirin was recommended. Based on our previous study, no visible effect of ribavirin therapy in improving clinical outcome was observed. Here we have accumulated the sample size to 634, and by performing prospective observation on the clinical progress and laboratory parameters, we found a significantly higher incidence of anemia and hyperamylasemia in patients who received ribavirin therapy in comparison with those who received no therapy. Generalized estimating equation model disclosed a significant effect on hemoglobin reduction and blood amylase augmentation from ribavirin administration. The occurrence of anemia and hyperamylasemia was associated with SFTS patients receiving ribavirin therapy, which might be adverse event of this drug administration. The recommendation of ribavirin for treating SFTS should be applied with caution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 119, July 2015, Pages 19-22
Journal: Antiviral Research - Volume 119, July 2015, Pages 19-22
نویسندگان
Qing-Bin Lu, Shu-Yan Zhang, Ning Cui, Jian-Gong Hu, Ya-Di Fan, Chen-Tao Guo, Shu-Li Qin, Zhen-Dong Yang, Li-Yuan Wang, Hong-Yu Wang, Xiao-Ai Zhang, Wei Liu, Wu-Chun Cao,