کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5822058 | 1557826 | 2015 | 5 صفحه PDF | دانلود رایگان |
- The natural compound OSW-1 is a potent broad spectrum inhibitor of enterovirus replication.
- OSW-1 inhibits enterovirus genome replication.
- OSW-1 is effective at low nanomolar concentrations in all cell lines tested.
- OSW-1 inhibits replication by targeting oxysterol-binding protein.
Enteroviruses, e.g., polio-, coxsackie- and rhinoviruses, constitute a large genus within the Picornaviridae family of positive-strand RNA viruses and include many important pathogens linked to a variety of acute and chronic diseases. Despite their huge medical and economic impact, no approved antiviral therapy is yet available. Recently, the oxysterol-binding protein (OSBP) was implicated as a host factor for enterovirus replication. Here, we investigated the antiviral activity of the natural compound OSW-1, a ligand of OSBP that is under investigation as an anti-cancer drug. OSW-1 potently inhibited the replication of all enteroviruses tested, with IC50 values in the low nanomolar range, acted at the genome replication stage and was effective in all tested cell types of three different species. Importantly, OSBP overexpression rescued viral replication, demonstrating that the antiviral effect of OSW-1 is due to targeting OSBP. Together, we here report the anti-enterovirus activity of the natural anti-cancer compound OSW-1.
Journal: Antiviral Research - Volume 117, May 2015, Pages 110-114