کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5822139 | 1557832 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Additive protection induced by mixed virus-like particles presenting respiratory syncytial virus fusion or attachment glycoproteins
ترجمه فارسی عنوان
محافظت اضافی ناشی از ذراتی مانند ویروس مانند که با هم ترکیب ویروس سینسیتیال تنفسی یا گلیکوپروتئین های دلبستگی ایجاد می شود
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Respiratory syncytial virus (RSV) is the most important pathogen for lower respiratory tract illness in infants and a high priority for vaccine development. We previously reported that RSV virus-like particles (VLPs) expressing either the fusion (F) or attachment (G) glycoprotein could confer protection against RSV challenge in BALB/c mice. Here, we tested the hypothesis that RSV VLP vaccine efficacy can be enhanced by mixing RSV VLP F and RSV VLP G, and we analyzed host responses to these RSV VLPs. Mice were immunized with VLP F, VLP G, or VLP FÂ +Â VLP G. Lung viral loads in BALB/c mice following RSV strain A2-line19F challenge were lower in mice vaccinated with RSV VLP FÂ +Â VLP G compared to VLP F- or VLP G-vaccinated mice. Vaccination with VLP F or VLP FÂ +Â VLP G induced similar levels of neutralizing antibodies. The enhanced protection against RSV challenge induced by vaccination with RSV VLP FÂ +Â VLP G correlated with CD8 T cells producing T helper type 1 cytokines. VLP G vaccination alone followed by challenge resulted in immunopathology similar to formalin-inactivated RSV vaccination and RSV challenge. Taken together, mixed VLP FÂ +Â VLP G provided a high level of protection against RSV without vaccine-induced immunopathology, but VLP G vaccination enhanced disease when used alone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 111, November 2014, Pages 129-135
Journal: Antiviral Research - Volume 111, November 2014, Pages 129-135
نویسندگان
Sujin Lee, Fu-Shi Quan, Youngman Kwon, Kaori Sakamoto, Sang-Moo Kang, Richard W. Compans, Martin L. Moore,