کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5822195 1557834 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new antiviral: Chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
A new antiviral: Chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo
چکیده انگلیسی
Although more-recently developed antivirals target different molecules in the HIV-1 replication cycle, nucleoside reverse transcriptase inhibitors (NRTIs) remain central for HIV-1 therapy. Here, we test the anti-HIV activity of a phosphonate chimera of two well-known NRTIs, namely AZT and 3TC. We show that this newly synthesized compound suppressed HIV-1 infection in lymphoid tissue ex vivo more efficiently than did other phosphonates of NRTIs. Moreover, the new compound was not toxic for tissue cells, thus making the chimeric phosphonate strategy a valid approach for the development of anti HIV-1 compound heterodimers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 109, September 2014, Pages 125-131
نویسندگان
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