کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5822330 | 1117939 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Inhibition of hepatitis C virus infection by polyoxometalates Inhibition of hepatitis C virus infection by polyoxometalates](/preview/png/5822330.png)
- POM-12, a polyoxometalate compound, efficiently inhibits HCV infection.
- POM-12 displays little cytotoxicity.
- POM-12 is virucidal and can disrupt HCV particles.
- POM-12 has weak inhibitory effect on VSV and influenza virus infection.
Hepatitis C virus (HCV) infects about 2% of the world population. The standard treatment of chronic HCV infection is still discontented because of the low sustained virological response rate. The development of new HCV antivirals is a healthcare imperative. We explored the potentials of polyoxometalates to inhibit HCV infection using newly developed HCVcc cell culture system. We found one polyoxometalate compound (named POM-12) can inhibit HCV infection at the nanomolar range while displayed little cytotoxicity. We showed that POM-12 inhibited pseudotyped HCV infection but had no effect on HCV RNA replication. Furthermore, we showed that POM-12 was virucidal and can disrupt HCV particles. Finally we demonstrated that POM-12 had no effect on the vesicular stomatitis virus infection while had weak inhibitory activity against the influenza virus infection. In conclusion, we identified a potent anti-HCV compound which may provide an attractive drug candidate to cure HCV infection.
Journal: Antiviral Research - Volume 100, Issue 2, November 2013, Pages 392-398