IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production

► Lambda interferons suppress HIV-1 integration and post-transcriptional events in vitro. ► IL-29 negatively correlates with IFN-γ and positively correlates with IL-10 in vivo. ► Lambda interferons show limited in vivo repression of viral production.