Inoculation of newborn mice with non-coding regions of foot-and-mouth disease virus RNA can induce a rapid, solid and wide-range protection against viral infection

► FMDV NCRs have prophylactic and therapeutic activity against viral infection. ► FMDV IRES induces heterotypic protection against virus challenge in suckling mice. ► FMDV 5′ and 3′ NCR transcripts induce dose-dependent protection against FMDV.