Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B

► The prevalence and susceptibility to LAM and ADV of the hepatitis B virus rtN238H mutation. ► Frequently occur in genotype B-infected patients, even without exogenous selection pressures. ► Do neither impair the viral replication efficiency nor susceptibility to LAM or ADV in vitro.