A dual chicken IgY against rotavirus and norovirus

► IgY against both RV and NoV were produced by immunizing chickens with a dual vaccine candidate P-VP8∗. ► The resulting IgY blocked RV and NoV binding to their HBGA receptors. ► The IgY is also able to neutralize RV replication in cell culture condition. ► The P-VP8∗ based IgY is a promising approach for passive immunization against both RV and NoV.