In vitro inhibition of Japanese encephalitis virus replication by capsid-targeted virus inactivation

► CTVI have been extensively investigated against the Flavivirus and Pestivirus. ► It is firstly reported the feasibility of using CTVI against JEV infection. ► Expressed Cap-SNase could be use to efficiently inhibit JEV replication. ► CTVI approach will be applicable to JEV inhibition as a novel anti viral strategy.