Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency

► Development of FMDV type O virus like particles (VLP) in insect cell line. ► Evaluation of the efficacy and immunogenicity of the VLP vaccine in cattle. ► The 50% protective dose of the VLP vaccine formulation was 5.01.