Neutralization of dengue virus in the presence of Fc receptor-mediated phagocytosis distinguishes serotype-specific from cross-neutralizing antibodies

► Distinguishing serotype-specific from cross-neutralizing antibodies is important. ► Convalescent sera neutralize homologous but not heterologous serotype intracellularly. ► This approach can clarify the serotype of the infection and hence immunity serologically. ► Our findings could serve vaccine and therapeutic antibody selection for development.