The antiviral activity and mechanism of action of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] (HPMP) nucleosides

► HPMP nucleosides are analogs of deoxynucleoside monophosphates. ► The HPMP nucleosides inhibit a wide range of DNA viruses. ► The HPMP nucleosides have a complex mechanism of action against viral polymerases. ► The development of resistance to the HPMP nucleosides has been described.