Safety and efficacy of tenofovir/IQP-0528 combination gels - A dual compartment microbicide for HIV-1 prevention

► Tenofovir/IQP-0528 microbicide combination gels were tested for safety and efficacy. ► Polarized ectocervical and colorectal tissues were used to evaluate these gels. ► Combination gels were safe toward mucosal tissue and blocked HIV infection. ► These gels provide the foundation of a dual compartment, combination product microbicide.