کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5823020 | 1117994 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells](/preview/png/5823020.png)
چکیده انگلیسی
Using RNAhybrid software we found the predicted binding of complementary sequences between miR-122 and viral mRNAs, may be important for the antiviral effect of miR-122 on Borna disease virus (BDV). A moderate expression of miR-122 was identified in human oligodendroglial cells (OL), but with a much lower level of miR-122 in BDV persistent infection (OL/BDV) and cells transfected with BDV gene expression vectors. Over-expression of miR-122 and specific blocking experiments demonstrated that miR-122 was able to specifically inhibit BDV protein synthesis, viral gene replication and transcription, and induce the secretion/synthesis of interferon (IFN) in OL and OL/BDV cells. The abolishment of miR-122 by AMO-122 inhibited endogenous IFN induction by IFN-beta. These results indicate that miR-122 can exert direct antiviral function by inhibiting BDV translation and replication on one hand, while acting indirectly through IFN to increase the host innate immunity to modulate the virus-host interactions on the other hand.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 87, Issue 2, August 2010, Pages 249-256
Journal: Antiviral Research - Volume 87, Issue 2, August 2010, Pages 249-256
نویسندگان
Jun Qian, Aixia Zhai, Wenping Kao, Yujun Li, Wuqi Song, Yingmei Fu, Xiaobei Chen, Qingmeng Zhang, Jing Wu, Hui Li, Zhaohua Zhong, Hong Ling, Fengmin Zhang,