Alleviation of collagen-induced arthritis by the benzoxathiole derivative BOT-4-one in mice: Implication of the Th1- and Th17-cell-mediated immune responses

BOT-4-one exerts an anti-arthritic activity by suppressing the polarization of Th1- and Th17-cell subsets through inhibition of the STAT, MAPK and NF-κB signaling.