Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines

Novel synthetic syrbactin analogs trigger endoplasmic reticulum stress (induction of CHOP, ATF-3), downregulate anti-apoptotic proteins (survivin, Mcl-1), and cause apoptosis (activation of caspase 3, cleavage of PARP).