کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5824322 | 1118507 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Salviae Mitiorrhizae and Cortex Moutan extract on the rat heart after myocardial infarction: A proteomic study
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کلمات کلیدی
CK-MBAMPADPSDDAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPadenosine diphosphate - آدنوزین دی فسفاتadenosine monophosphate - آدنوزین مونوفسفرهIschemia - ایسکمیcoronary heart disease - بیماری عروق کرونر قلبHerbal medicine - داروی گیاهیDrug treatment - درمان داروییEnergy metabolism - متابولیسم انرژیNitric oxide - نیتریک اکسیدProtein profiling - پروفیل پروتئینCreatine kinase - کراتین کینازcreatine kinase-MB - کراتین کیناز MB
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
In this study, we characterized the therapeutical effects of Salviae Mitiorrhizae (Danshen) and Cortex Moutan (Danpi) extract (SDD) on Sprague-Dawley rats subjected to coronary artery ligation, and applied proteomic approach to investigate its potential mechanism of action. The chemical composition of SDD was investigated by HPLC/MSn analysis. Measurement for serum levels of creatine kinase (CK), creatine kinase-MB (CK-MB), nitrite and histological study for infarct area of heart were performed. Moreover, protein abundance profiles of myocardium were compared by two-dimensional gel electrophoresis and altered proteins were identified by MALDI-TOF-MS. The results showed SDD significantly decreased CK, CK-MB concentration in serum and infarct area of heart, while increased the release of nitrite in rats with coronary occlusion. Increased concentration of ATP and total adenine nucleotide indicated the energy metabolism has been improved in ischemic heart induced by SDD. Proteomic data revealed that 23 proteins associated with energy metabolism, oxidative stress and cytoskeleton were modulated in SDD treated rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 74, Issue 3, 1 August 2007, Pages 415-424
Journal: Biochemical Pharmacology - Volume 74, Issue 3, 1 August 2007, Pages 415-424
نویسندگان
Yi Wang, Li Liu, Chuchu Hu, Yiyu Cheng,