Serum profiles of matrix metalloproteinases and their tissue inhibitors in long-term pulmonary complication induced by sulfur mustard: Sardasht-Iran Cohort Study (SICS)

► MMP-1 is produced by type II penumocytes and may be associated with lung complication via hydrolysis of fibrillar collagen. ► Lowe MMP-2 activity levels may cause excessive ECM deposition and disturb gas exchange in alveolar space. ► A significant increase was found in the serum level of MMP-1 in the exposed group with moderate to severe pulmonary complications. ► A significant decrease of MMP-2 activity was observed in exposed groups with mild pulmonary symptoms. ► These changes may be participate to the alteration of proteolysis/anti-proteolysis balance and lead to SM induced lung problems.